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Losing weight and keeping it off can minimize the many health risks associated with obesity, including heart disease, diabetes, high blood pressure, and a shorter life. As a result, Naltrexone is a class of drugs known as opiate antagonists, and bupropion is an antidepressant that can help restore the balance of certain natural chemicals (neurotransmitters) inside the brain. Such two drugs work together to suppress the appetite and how much you feed on different parts of the brain.